[ref. n8112121] Senior Scientist, Discovery Chemistry - MGD

Overview:

Monte Rosa Therapeutics (MRT) seeks to recruit an enthusiastic, creative and highly talented medicinal chemist who is eager to discover molecular glue degraders (MGDs) that eliminate disease-causing proteins previously thought undruggable.

This position plays a key role in contributing to the development of our growing portfolio and will have a crucial impact at the forefront of drug discovery. The successful candidate should have strong interest in early-stage drug discovery, prior experience in HTS data analysis, hit follow-up as well as utilizing state-of-the-art medicinal chemistry knowledge up to the Lead Identification phase.

Responsibilities:

• Analyze High Throughput Screening (HTS) output with the goal of identifying promising starting points for hit generation chemistry from our growing MGD library.
• Serve as chemistry project lead against multiple early-stage projects.
• Develop hit follow up and lead generation strategy for discovery targets in collaboration with discovery scientists.
• Create structure activity relationship driven hypotheses for follow-up experiments to probe target engagement in hit validation.
• Provide tool compounds and contribute to target validation efforts as member of a cross-functional discovery team.
• Provide chemistry progressability assessments for early targets.
• Familiarity with key concepts and optimization strategies in medicinal chemistry including a clear understanding of ADME properties.
• Efficient and timely execution of compound syntheses through our CRO network, by devising efficient synthetic routes.
• Collaborate with external research partners.
• Communicate scientific findings and project updates to senior leadership and governance.
• Summarize and publish findings in manuscripts and patents when appropriate.

Qualifications:

• PhD in synthetic organic /medicinal chemistry or equivalent experience with a history of applicable publications in small molecule drug discovery.
• 4 to 8 years of relevant professional experience in hit and lead generation chemistry.
• Deep experience of High Throughput Screening analysis and follow-up.
• Familiarity with early stages of pre-clinical research in drug discovery.
• High level of proficiency with databases, data analysis and visualization tools (e.g. Spotfire, D360, CDD, Maestro, Pymol).
• Proficiency in complex molecule synthesis and/or synthetic method development experience.
• Needs to be highly effective in cross-functional and cross-site teams.
• Experience of collaborating with CROs is essential.
• Excellent written and oral communication skills.