Scientist III - Cambridge - ref. q95323719
Companys neuroscience research enterprise in Cambridge, MA - the Cambridge Research Center (CRC) is focused on uncovering the fundamental biological mechanisms underpinning neurodegenerative diseases, including Alzheimers and Parkinsons disease.
We are expanding our research team focused on Parkinsons Disease (PD) to discover and develop disease-modifying therapeutics for this devastating disease.
We are seeking a highly motivated Scientist with expertise in cellular/molecular biology to join the Parkinsons Biology Area team for a 12-month contract position. As a member of our team, you will work closely with the research team to develop in vitro models to validate novel drug discovery targets, as well as identify and characterize drug leads and candidates.
Responsibilities: Establish strong scientific and technical initiatives and hands-on implementation for new in vitro models
Execution of in vitro experiments to create cellular models in immortalized cell lines, primary neurons and/or iPSC-derived neuronsBuild and execute biochemical and cell-based assays to support novel PD target validation
Collaborate with and support cellular and molecular biologists, in vivo pharmacologists and medicinal chemists across global research sites
Present research at internal meetings
Requirements:Bachelors or masters degree in molecular biology, with typically 5+ (BS), 2+ (MS) years of experience; Pharmaceutical industry experience preferred
High level of expertise with gene transfection (conceptualization, vector design and execution), clonal cell line selection and maintenance
Proficiency with standard cell and molecular biology, biochemistry, enzymology and neuroscience techniques including gene transfer methods, microscopy and high-content imaging, protein detection & quantification (such as ELISA, MSD), and enzyme kinetic assays
Extensive bench research experience and enjoy a laboratory-focused role in a fast-paced, multidisciplinary team
Ability to design, execute and interpret experiments independently
Excellent written and verbal communication
Strong interpersonal and teamwork skills paired with a strong work ethic
Strong organizational skills that enable multitasking and working within timelines
Background in cell biology, neuroscience and/or neurodegenerative disease mechanisms (protein aggregation etc.) considered a plus