Scientist - Bioanalysis

Company Description:

Insmed is a global biopharmaceutical company on a mission to transform the lives of patients living with serious and rare diseases. Our most valuable resource is our employees, and everything we do is motivated by a patients-first mentality. We are dedicated to growing our team with talented individuals from around the world who are willing to challenge the status quo, solve problems, and work collaboratively with a sense of urgency and compassion.

If you share our vision and want to work with the most dedicated people in the biopharma industry, come to Insmed to accelerate your career.

Recognitions:

Consistently Ranked Science’s Top Employer

Insmed is dedicated to creating a collaborative environment where our team can thrive. Every day, our employees turn their passion for science and research into innovative solutions for patients. That’s why we’ve been named the No. 1 company to work for in the biopharma industry in Science’s Top Employers survey for four years in a row.

A Certified Great Place to Work®

We believe our company is truly special, and our employees agree. In July 2024, we became Great Place to Work-certified in the U.S. for the fourth year in a row. We are also honored to have been listed on the Best Workplaces in Biopharma™, Best Workplaces in New York™, PEOPLE® Companies That Care, Best Workplaces for Women™, Best Workplaces for Millennials™, and Best Medium Workplaces™ lists.

We are seeking a talented and motivated Scientist - Bioanalysis to work with a multidisciplinary team of scientists focused on the development, validation, and execution of various bioanalytical assays related to pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity testing.

Responsibilities:

• Develop various types of ELISA assays (e.g., competitive, sandwich, indirect) tailored to specific applications.
• Perform PK sample analysis of large molecules and ASOs using ELISA and MSD.
• Perform and interpret cell-based potency assays, including ADCC for drug efficacy testing.
• Employ phage display techniques to discover small peptides.
• Summarize experimental data into technical reports and present scientific findings to internal teams and external collaborators.
• Maintain proper documentation of experimental procedures and results via electronic laboratory notebooks.
• Ensure adherence to regulatory guidelines for method development and validation.
• Potentially manage and train junior scientists or research associates.
• The candidate may be asked to help other team members for MS related tasks and be trained with MS related workflow.

Qualifications/Requirements:

• Master's Degree in Biochemistry, Immunology, Molecular Biology, Analytical Chemistry, or a related discipline with 5+ years of industrial experience in bioanalytical method development.
• Hands-on experience with ELISA, MSD, cell-based assays (e.g., ADCC), and immunogenicity testing.
• Experience with phage display technology and small peptide discovery is highly desirable.
• Strong knowledge of PK and PD concepts and experience with PK method validation.
• Excellent verbal and written communication skills, and ability to work in a collaborative research environment.
• High degree of motivation, creativity, and attention to detail.

Technical Requirements:

• Experience in optimizing assay conditions, including buffer composition, pH, incubation times, and temperatures.
• Knowledge of validation protocols to ensure accuracy, precision, sensitivity, specificity, and reproducibility of ELISA methods.
• Knowledge of sourcing, storing, and preparing antibodies and other reagents (e.g., enzymes, substrates) for ELISA assays.
• Experience with antibody characterization techniques to ensure specificity and affinity.
• Candidates with relevant experience in aptamer-based protein affinity techniques and familiarity with SELEX (Systematic Evolution of Ligands by Exponential Enrichment) for screening and optimizing aptamers are highly desirable.

In-depth Understanding of ECL Technology:

• Ability to design MSD assays for a wide range of applications, such as pharmacokinetics (PK), pharmacodynamics (PD), immunogenicity, and biomarker detection. Proficiency in selecting appropriate antibodies, antigens, and calibrators for specific assay requirements.
• Expertise in optimizing critical parameters such as incubation times, reagent concentrations, and washing steps to maximize assay performance. Experience with troubleshooting and iterative refinement of protocols to improve signal-to-noise ratios and assay reproducibility.
• Ability to optimize signal strengths for each analyte within a multiplex assay, ensuring that weaker signals are still detectable without overwhelming stronger signals.
• Proficiency in validating MSD assays according to regulatory standards, ensuring the assay's accuracy, precision, sensitivity, specificity, and reproducibility. Familiarity with regulatory guidance (e.g., FDA, EMA) for bioanalytical method validation.

Biomarker Qualification:

• Experience in qualifying biomarkers in preclinical studies. Understanding how to establish validation parameters for biomarkers with low or variable expression in different biological matrices.
• Knowledge of sample stability, storage conditions, and processing to minimize degradation or loss of analytes, particularly for sensitive biomarkers or therapeutic agents like ASOs

#LI-MM1

Salary Range: $89,000 - $119,267 a year

Compensation & Benefits:

We’re committed to investing in every team member’s total well-being, now and in the future. We offer a competitive total-rewards package to all employees around the world, including:

• Flexible approach to where and how we work, regionally based
• Competitive compensation package including bonus
• Stock options and RSU awards
• Employee Stock Purchase Plan (ESPP)
• Flexible Vacation Policy
• Generous paid holiday schedule and winter break

ADDITIONAL U.S. BENEFITS:

• 401(k) plan with company match
• Medical, dental, and vision plans
• Company-provided Life and Accidental Death & Dismemberment (AD&D) insurance
• Company-provided short and long-term disability benefits
• Unique offerings of pet, legal, and supplemental life insurance
• Flexible spending accounts for medical and dependent care
• Accident and Hospital Indemnity insurance
• Employee Assistance Program (EAP)
• Mental Health on-line digital resource
• Well-being reimbursement
• Paid leave benefits for new parents
• Paid time off to volunteer
• On-site, no-cost fitness center at our U.S. headquarters

Additional Information:

Insmed Incorporated is an Equal Opportunity/Affirmative Action employer. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law.

The Human Resources department is responsible for all recruitment activities; please contact us directly to be considered for a formal agreement.

Requests for accommodation will be considered on a case-by-case basis. Please note that only inquiries concerning a request for reasonable accommodation will be responded to from this email address.

Applications are accepted for 5 calendar days from the date posted or until the position is filled.